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Your Position: Home > Complement component 3

Complement component 3

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ACRO Quality

Part of Bioactivity data

CO3-H5253-MALS-HPLC
Complement component 3 MALS images

The purity of Human Complement component 3 Protein, Fc Tag (Cat. No. CO3-H5253) is more than 85% and the molecular weight of this protein is around 390-440 kDa verified by SEC-MALS.

CO3-H5253-ELISA
Complement component 3 ELISA

Immobilized Human Complement component 3 Protein, Fc Tag (Cat. No. CO3-H5253) at 1 μg/mL (100 μL/well) can bind Anti-C3 antibody with a linear range of 0.1-4 ng/mL (QC tested).

Protocol

Synonym Name

Complement C3,CPAMD1

Background

C3 is the major complement component serum. It is mainly synthesized by macrophages and liver. C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. It is cleaved into two fragments, C3a and C3b. C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

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